. 2020 Sep 17;22(5):4151–4162. doi: 10.3892/mmr.2020.11521

Table II.

mRNA expression of myocardial genes in CON (n=8), DOX (n=12) and DOX+Val (n=12) groups.

Gene	CON (mean ± SD)	DOX (mean ± SD)	DOX+Val (mean ± SD)
Bax	0.005472±0.002241	0.579347±0.015441^a	0.016487±0.002301^a,b
Collagen I	0.000159±0.000117	0.003708±0.001421^a	0.000743±0.000246^a,b
BNP	0.008863±0.000374	0.033877±0.011124^a	0.015468±0.003612^b
Beclin-1	0.070218±0.038941	0.496883±0.027112^a	0.408002±0.014891^a,b
BCL2	0.069447±0.024328	0.005516±0.002308^a	0.011095±0.006306^b
NOX4	2.660319±0.722017	23.744164±9.831247^a	4.283176±0.274911^a,b
NOX1	0.329351±0.027661	0.715372±0.196175^a	0.616009±0.201272
NOX2	0.005916±0.002794	0.085991±0.008259^a	0.008974±0.000806^a,b
Caspase-3	0.000813±0.000582	0.004873±0.003057^a	0.002485±0.001034^a,b
MMP9	0.000110±0.000222	0.001814±0.000453^a	0.000134±0.000177^a,b
MMP2	0.106209±0.082461	0.409883±0.172409^a	0.160207±0.036443^a,b
ANP	1.263391±0.404303	7.823333±2.880115^a	2.786022±0.582717^a,b
β-MHC	1.473521±0.610019	24.508593±9.604317^a	3.712543±1.140049^a,b
BGN	3.914408±0.593123	0.594062±0.097032^a	0.038563±0.004427^a,b
TPM1	0.007855±0.003824	0.002717±0.001296^a	0.000702±0.000241^a,b
Collagen III	0.017781±0.003225	0.000461±0.000158^a	0.001982±0.000791^a,b
CORIN	0.245495±0.074003	0.030678±0.028541^a	0.016321±0.008023^a
TGF-β1	0.013657±0.004844	0.039625±0.011513^a	0.022389±0.012937
GDF15	0.003563±0.001879	0.044461±0.013455^a	0.004693±0.000264^a,b
POSTN	0.003533±0.002247	0.530036±0.110447^a	0.020532±0.006552^a,b

P<0.05 vs. CON group

P<0.05 vs. DOX group. CON, control; DOX, doxorubicin; Val, valsartan; NOX, NAD(P)H oxidase; BNP, brain natriuretic peptide; MMP, matrix metallopeptidase; ANP, atrial natriuretic peptide; β-MHC, β myosin heavy chain; GDF15, growth differentiation factor 15; TPM1, tropomyosin 1; BGN, biglycan; POSTN, periostin; CORIN, atrial natriuretic peptide-converting enzyme; TGF-β1, transforming growth factor β1.