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. 2020 Sep 2;22(5):3715–3722. doi: 10.3892/mmr.2020.11489

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Copyright: © Xiang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — SNHG1 overexpression alleviates BMSC osteogenesis differentiation by targeting miR-101. (A) miR-101 and DKK1 expression levels in BMSCs transfected with miR-101 mimics and mimics-NC. (B) DKK1 expression levels in BMSCs following co-transfection with pcDNA-SNHG1 and miR-101 mimics. (C) The expression levels of RUNX2, OPN and OCN expression in BMSCs co-transfected with pcDNA-SNHG1 and miR-101 mimics. (D) ALP activity and (E) Alizarin Red staining in BMSCs co-transfected with pcDNA-SNHG1 and miR-101 mimics. *P<0.05, **P<0.01 and ***P<0.001. SNHG1, small nucleolar RNA host gene 1; BMSC, bone mesenchymal stem cell; miR, microRNA; DKK1, dickkopf WNT signaling pathway inhibitor 1; NC, negative control; RUNX2, RUNX family transcription factor 2; OPN, osteopontin; OCN, osteocalin.