Table 1:

Time metrics in the treatment of acute ischemic stroke patients before and after the declared regional social and healthcare restrictions

	After SHR	Before SHR	p-value
Intravenous thrombolysis with tPA
Number of patients	12	97
Age (years, median, IQR)	68 (56–78)	74 (64–85)	0.220
NIHSS score on admission (median, IQR)	8 (4–12)	12 (8–19)	0.010
Onset-to-door time (min, median, IQR)	55 (45–74)	64 (44–92)	0.480
ER triage time (min, median, IQR)	5 (3–7.5)	4 (3–6)	0.888
Door-to-CT time (min, median, IQR)	19 (14–27)	13 (9–17)	0.008
CT-to-needle time (min, median, IQR)	38 (26–46)	24 (17–33)	0.023
Door-to-needle time (min, median, IQR)	61 (46–72)	37 (30–50)	0.005
Onset-to-treatment time (min, median, IQR)	121 (87–183)	104 (77–147)	0.394
Endovascular thrombectomy
Number of patients	18	154
Age (years, median, IQR)	68 (62–84)	74 (62–83)	0.681
NIHSS score on admission (median, IQR)	17 (13–21)	18 (14–22)	0.602
Transfer from primary stroke center (%)	55.5%	63.6%	0.502
tPA pretreatment (%)	70.5%	45.8%	0.052
Door-in-to-door-out time (min, median, IQR)*	94 (79–116)	91 (79–110)	0.656
Onset-to-door time (min, median, IQR)	154 (90–226)	235 (145–415)	0.037
Door-to-CT time (min, median, IQR)	20 (15–33)	11 (5–20)	0.035
Angiography suite arrival to groin puncture time (min, median, IQR)	19 (16–22)	16 (13–20)	0.022
Door-to-groin puncture time (min, median, IQR)	60 (33–110)	43 (29–82)	0.391
Onset-to-groin puncture time (min, median, IQR)	238 (180–275)	293 (201–453)	0.164
Door-to-recanalization (min, median, IQR)	117 (62–139)	77 (58–123)	0.348

ER = emergency room; IQR = interquartile range; NIHSS = National Institutes of Health Stroke Scale; SHR = social and healthcare restrictions; tPA = tissue plasminogen activator.

^*For patients transferred from a primary center for endovascular thrombectomy.