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. 2020 Sep 2;22(5):3785–3794. doi: 10.3892/mmr.2020.11486

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Copyright: © Mou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Circ_0000491 targets miRNA-101b. (A) The miR-101b mRNA expression levels in MES13 cells transfected with miR-101b mimics or miR-101b inhibitor was confirmed using RT-qPCR. (B) Circ_0000491 expression was examined in the transfected MES13 cells. (C) Diagram of the miR-101b putative binding sites in circ_0000491. (D) miR-101b expression in db/db mice and high glucose treated MES13 cells was measured using RT-qPCR. (E) Luciferase reporter assay showed the binding activity of miR-101b and circRNA_0000491. (F) miR-101b mRNA expression levels in MES13 cells transfected with si_circ_0000491 was measured using RT-qPCR. *P<0.05, **P<0.01 vs. the corresponding control group. circRNA, circular RNA; miR/miRNA, microRNA; RT-qPCR, reverse transcription-quantitative PCR; si, small interfering.