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Human anti-TLR4 IgG2 protects mice from LPS-induced lethal sepsis. Mice were intravenously injected with human anti-TLR4 IgG2 (15 µg/g) or equal dose of PBS at 2 h before exposure to LPS (15 µg/g). The number of mice surviving the challenge was shown. N=13. ***P<0.001 vs. LPS group. LPS, lipopolysaccharide; TLR4, Toll-like receptor 4; L, LPS; A, human anti-TLR4 IgG2.
