Figure 4.

miR-155-5p targets SIRT1 in human nasal epithelial cells. (A) Sequences of SIRT1-WT (top), miR-155-5p (middle) and SIRT1-MUT (bottom) used to predict that SIRT1 may be a potential target of miR-155-5p. (B) Dual-luciferase reporter assays confirmed that SIRT1 was a target of miR-155-5p. **P<0.01, vs. IC. Experiments were performed in triplicate. Data are presented as the mean ± standard deviation. miR, microRNA; SIRT1, sirtuin 1; WT, wild-type; MUT, mutant; IC, inhibitor control; I, miR-155-5p inhibitor.