Table II.
Top 20 genes in the PPI network of genes associated with lipopolysaccharide treatment.
| A, Top 20 genes based on degree | |
|---|---|
| Gene | Degree |
| Fpr1a | 27 |
| Cxcl2a | 26 |
| Cxcl10a | 24 |
| C5ar1 | 23 |
| Fpr2a | 22 |
| Cxcl3a | 21 |
| Ccr1 | 20 |
| Ccl4 | 20 |
| Bdkrb1 | 19 |
| Ccl9 | 19 |
| Anxa1 | 19 |
| Ccl5 | 19 |
| Nfkb1a | 19 |
| Gm21104 | 18 |
| Gpsm2 | 17 |
| Hcar2 | 17 |
| Cxcl13 | 17 |
| Ccl20 | 17 |
| Il6a | 15 |
| Tnfa | 15 |
| B, Top 20 genes based on betweenness | |
| Gene | Betweenness |
| Il6a | 3,750.5457 |
| Cxcl10a | 2,844.6838 |
| Nfkb1a | 2,505.5789 |
| Tnfa | 2,152.0164 |
| Ifit1 | 1,969.5000 |
| Fpr1a | 1,809.1663 |
| Cxcl2a | 1,700.6371 |
| Orm1 | 1,651.6079 |
| Jak2 | 1,479.5116 |
| Tlr2 | 1,104.2716 |
| Socs3 | 1,070.4786 |
| Csf2 | 1,046.3145 |
| Cxcl3a | 813.3837 |
| Il1b | 801.5933 |
| Vnn1 | 690.0000 |
| Timp1 | 662.3790 |
| Tnfaip3 | 609.1126 |
| Fpr2a | 561.2064 |
| Tmem173 | 525.8387 |
| Tbk1 | 519.1886 |
| C, Top 20 genes based on closeness | |
| Gene | Closeness |
| Cxcl2a | 0.02045 |
| Il6a | 0.02043 |
| Cxcl10a | 0.02042 |
| Tnfa | 0.02040 |
| Nfkb1a | 0.02039 |
| Ccl5 | 0.02037 |
| Cxcl3a | 0.02036 |
| Tlr2 | 0.02035 |
| Il1b | 0.02035 |
| Ccl4 | 0.02035 |
| Fpr1a | 0.02034 |
| Ccl2 | 0.02032 |
| C5ar1 | 0.02032 |
| Ccr1 | 0.02031 |
| Fpr2a | 0.02030 |
| Bdkrb1 | 0.02029 |
| Ccl9 | 0.02029 |
| Anxa1 | 0.02029 |
| Gm21104 | 0.02028 |
| Orm1 | 0.02028 |
a
In the top 20 by degree, betweenness and closeness values.