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. 2020 Sep 15;11:546439. doi: 10.3389/fphar.2020.546439

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Copyright © 2020 AlQathama, Ezuruike, Mazzari, Yonbawi, Chieli and Prieto

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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2D anti-migratory effects of fractions of active plant extracts with inhibitory effect at both GI₅₀ and MNTC on B16-F10 murine melanoma cells after 24 h. Area of the gap (measured in pixels) in a confluent cell monolayer immediately after gap generation (0 h) and at 24 h post-wounding. HU: Hydroxyurea (reference compound, 75 µM); C: chloroform fraction; B: butanol fraction; W: water fraction. Data are presented as the mean ± SD (n = 3), (***) p < 0.001; (**) p < 0.01; (*) p < 0.05, respectively.