Table 3.

Summary and comparison of percent change in biomarkers between loss, no change, and gain groups.

Percent (%) change (Δ) in biomarker, %	Loss (N = 13)	No change (N = 18)	Gain (N = 17)	P-value
				All groups	Loss vs. Gain
%Δ FGF-21	0 (−22, 17)	2 (−17, 70)	35 (2, 113)	0.22	0.052
%Δ Adiponectin	11 (−8, 54)	35 (9, 45)	−6 (−24, 10)	0.005	0.020
%Δ Leptin	2 (−16, 10)	−6 (−14, 27)	6 (−8, 35)	0.39	0.16
%Δ FAR	−24 (−32, 5)	−13 (−43, 31)	76 (24, 118)	0.011	0.005
%Δ LAR	−18 (−35, 1)	−18 (−32, −1)	23 (−16, 56)	0.016	0.014
%Δ Weight	4 (−2, 6)	2 (−1, 5)	6 (4, 8)	0.17	0.31
%Δ BMI z-score	−1 (−2, 2)	−1 (−3, 3)	2 (−0, 3)	0.10	0.063
%Δ Percent body fat	−0 (−1, 1)	−2 (−4, 0)	1 (−1, 4)	0.053	0.34
%Δ Waist circumference	1 (0, 2)	1 (0, 6)	2 (1, 6)	0.54	0.30
%Δ Fasting glucose	4 (−6, 12)	−5 (−9, 3)	−2 (−8, 2)	0.35	0.32
%Δ Insulin	−5 (−45, 36)	−14 (−38, 12)	31 (−12, 60)	0.13	0.26
%Δ HOMA-IR	10 (−35, 38)	−8 (−40, 11)	27 (−11, 80)	0.13	0.26
%Δ Triglyceride	2 (−25, 54)	−2 (−37, 8)	23 (2, 59)	0.097	0.39
%Δ HDL	−4 (−8, 6)	−2 (−13, 30)	−5 (−11, 6)	0.81	0.66
%Δ FFA	10 (−29, 36)	2 (−40, 27)	−14 (−23, 10)	0.76	0.52
%Δ ALT	−11 (−13, −6)	4 (−11, 9)	0 (−19, 29)	0.18	0.12
%Δ AST	0 (−6, 4)	0 (−6, 12)	17 (−10, 36)	0.22	0.16
%Δ GGT	0 (−8, 12)	3 (−6, 13)	11 (0, 33)	0.33	0.15

Statistics shown are median (1st quartile, 3rd quartile). P-values are calculated from Kruskal–Wallis test comparing all groups or Wilcoxon Rank-sum test comparing loss and gain group. ALT, alanine aminotransferase; AST, aspartate aminotransferases; BMI, body mass index; FAR, Fibroblast Growth Factor 21–Adiponectin Ratio; FFA, free fatty acid; FGF21, fibroblast growth factor 21; GGT, Gamma-Glutamyl Transferase; HDL, High- Density Lipoprotein; HOMA-IR, Homeostatic Model Assessment—Insulin Resistance; LAR, Leptin—Adiponectin Ratio; LDL, Low-Density Lipoprotein.