TABLE 1.
Spectra of 5812-A/C activity comprising known peptide antibiotics.
| Bacterial cell wall | Organisms | Drugs | Minimal inhibitory concentrations, μg/ml | Minimal bactericidal concentrations, μg/ml |
| Gram-positive | Staphylococcus aureus 209P (MSSA) | 5812-A/C | 0.8 | 0.8 |
| Daptomycin | 0.8 | 0.8 | ||
| Vancomycin | 3.8 | 3.8 | ||
| Nisin | 7.5 | 7.5 | ||
| Staphylococcus aureus (MRSA) | 5812-A/C | 3.1 | 3.1 | |
| Daptomycin | 0.7 | 0.7 | ||
| Vancomycin | 3.7 | 3.7 | ||
| Nisin | 1.9 | 1.9 | ||
| Enterococcus faecium ICIS 18 | 5812-A/C | >120 | >120 | |
| Daptomycin | 8.1 | 8.1 | ||
| Vancomycin | 1.6 | 1.6 | ||
| Nisin | 7.5 | 7.5 | ||
| Enterococcus faecium 79OSAU | 5812-A/C | >120 | >120 | |
| Daptomycin | 12.5 | 12.5 | ||
| Vancomycin | 0.7 | 0.7 | ||
| Nisin | 7.5 | 7.5 | ||
| Bacillus cereus IP 5832 | 5812-A/C | 3.8 | 7.5 | |
| Daptomycin | 4.1 | 8.1 | ||
| Vancomycin | 0.8 | 0.8 | ||
| Nisin | 3.9 | 7.8 | ||
| Gram-negative | Escherichia coli K12 | 5812-A/C | 60 | >120 |
| Daptomycin | >120 | >120 | ||
| Vancomycin | >100 | >100 | ||
| Nisin | 62.5 | >125 | ||
| Escherichia coli MG1655 | 5812-A/C | >120 | >120 | |
| Daptomycin | >120 | >120 | ||
| Vancomycin | >100 | >100 | ||
| Nisin | >125 | >125 | ||
| Pseudomonas aeruginosa ATCC 28753 | 5812-A/C | >120 | >120 | |
| Daptomycin | >120 | >120 | ||
| Vancomycin | >100 | >100 | ||
| Nisin | >125 | >125 | ||
| Salmonella enterica ATCC 14028 | 5812-A/C | >120 | >120 | |
| Daptomycin | >120 | >120 | ||
| Vancomycin | >100 | >100 | ||
| Nisin | >125 | >125 | ||
| Chromobacterium violaceum ATCC 31532 | 5812-A/C | >120 | >120 | |
| Daptomycin | >120 | >120 | ||
| Vancomycin | >100 | >100 | ||
| Nisin | >125 | >125 | ||
| Pectobacterium carotovorum VKM-B1247 | 5812-A/C | >120 | >120 | |
| Daptomycin | >120 | >120 | ||
| Vancomycin | >100 | >100 | ||
| Nisin | >125 | >125 |