TABLE 1.

Univariate and multivariate Cox regression analysis of SQLC.

Variables	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Age (≤65 vs. >65)	1.237 (0.908–1.686)	0.178	1.285 (0.932–1.771)	0.126
Gender (male vs. female)	0.899 (0.637–1.268)	0.544	0.800(0.562–1.138)	0.215
Tumor stage
T1	1		1
T2	1.274 (0.859–1.890)	0.229	1.302(0.862–1.969)	0.210
T3	1.972 (1.204–3.231)	0.007	2.245 (1.093–4.612)	0.028
T4	2.491 (1.308–4.744)	0.005	3.250 (1.288–8.196)	0.013
N stage
N0	1		1
N1	1.205 (0.862–1.684)	0.275	1.361 (0.780–2.374)	0.278
N2	1.405 (0.862–2.292)	0.173	1.521 (0.622–3.722)	0.358
N3	2.987 (0.733–12.174)	0.127	5.574 (1.005–30.929)	0.049
Clinical stage
I	1		1
II	1.235 (0.871–1.750)	0.236	0.918 (0.507–1.661)	0.777
III	1.784 (1.229–2.591)	0.002	0.874 (0.330–2.315)	0.787
IV	2.251 (0.707–7.166)	0.170	1.579 (0.419–5.959)	0.500
8-IRG risk score (low vs high)	1.600 (1.168–2.193)	0.003	1.937 (1.382–2.715)	<0.001

HR, hazard ratio; CI, confidence interval; IRG, immune-related genes.