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Haplolethal homing drive mechanism. Drive conversion occurs in the germline. Alternatively, if Cas9 cleavage is repaired by end joining, an r2 resistance allele is typically formed. Additional resistance alleles can form due to maternally deposited Cas9 and gRNAs in the embryos from mothers that had at least one drive allele. All embryos receiving an r2 resistance allele that disrupts the target gene (as shown in the figure) will be nonviable.
