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Drive construct design. (A) The drive construct contains a recoded version of RpL35A, DsRed, and two gRNAs. (B) The wild-type allele of RpL35A is cleaved in the second coding exon by the drive’s gRNAs. (C) The supporting element of the drive contains Cas9 with the nanos promoter and a 3′ UTR with an EGFP marker.
