Fig. 3.

Drive inheritance rate. Flies heterozygous for the drive and Cas9 alleles were crossed with w¹¹¹⁸ flies. The progeny of these were evaluated for drive inheritance, which was the percentage of flies with DsRed phenotype. Each data point represents the inheritance rate observed in one vial containing one drive parent. The size of each dot represents the clutch size in the vial based on the total number of adult offspring phenotyped. The rate estimates and corresponding estimates of the SEM are displayed, obtained from pooling offspring from all crosses of the same type together. An alternate analysis that accounts for potential batch effects was also performed but yielded overall similar rates with only slightly increased error estimates (Dataset S1 A and B).