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. 2020 Sep 10;117(39):24392–24402. doi: 10.1073/pnas.2007224117

Fig. 1.

Fig. 1.

NR4A3 restrains CD8+ T cell memory generation. (A) Effector and memory responses in the spleen of mice adoptively transferred with CD45.2+ Nr4a3+/+ or Nr4a3−/− OT-I cells prior to Lm-OVA infection. (B) Proportions of MPECs (CD127+KLRG1−) and SLECs (CD127−KLRG1+) within OT-I effectors at day 7 postinfection. (C) Nr4a3+/+ and Nr4a3−/− OT-I cells transduced with empty- or Nr4a3-encoding retrovirus (RV) were transferred into Lm-OVA-infected mice. At day 7 postinfection, MPEC and SLEC distribution in GFP+-transduced cells was evaluated. +/+: Nr4a3+/+ cells; −/−: Nr4a3−/− cells. Each dot represents one mouse. Data are from at least three independent experiments. Unpaired Student’s t test, with a Welch’s correction when applied, was used for two-group comparison and Kruskal–Wallis ANOVA with Dunn’s multiple comparison for multiple group comparison: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.