Table 2.

Thrombosis during follow-up in MPN patients

Type of thrombosis	Time after MPN diagnosis	All MPN HR 95% CI	PV HR 95% CI	ET HR 95% CI	PMF HR 95% CI
Overall	3 months	4.0 (3.6–4.4)	4.2 (3.5–5.0)	3.5 (2.9–4.2)	4.7 (3.6–6.0)
	1 year	2.4 (2.3–2.6)	2.5 (2.2–2.8)	2.2 (1.9–2.5)	2.7 (2.2–3.2)
	5 years	1.8 (1.6–1.9)	1.8 (1.6–2.0)	1.7 (1.5–1.9)	2.0 (1.7–2.4)
All arterial thrombosis	3 months	3.0 (2.7–3.4)	2.7 (2.2–3.3)	2.7 (2.2–3.3)	4.4 (3.4–5.9)
	1 year	2.0 (1.8–2.2)	1.9 (1.6–2.1)	2.0 (1.7–2.3)	2.3 (1.9–2.9)
	5 years	1.5 (1.4–1.6)	1.5 (1.3–1.7)	1.4 (1.3–1.6)	1.6 (1.3–1.9)
Myocardial infarction	3 months	2.5 (2.1–2.9)	2.1 (1.5–2.9)	1.8 (1.3–2.4)	5.3 (3.5–7.8)
	1 year	1.8 (1.6–2.0)	1.5 (1.2–1.9)	1.5 (1.2–1.8)	2.6 (2.0–3.5)
	5 years	1.4 (1.2–1.5)	1.2 (1.0–1.5)	1.4 (1.1–1.6)	1.6 (1.2–2.2)
Ischemic stroke	3 months	3.7 (3.1–4.4)	3.7 (2.8–5.0)	3.8 (2.8–5.1)	3.7 (2.4–5.7)
	1 year	2.3 (2.0–2.6)	2.3 (1.9–2.8)	2.6 (2.1–3.2)	1.8 (1.3–2.5)
	5 years	1.5 (1.3–1.6)	1.4 (1.2–1.7)	1.5 (1.3–1.8)	1.5 (1.1–2.0)
All venous thrombosis	3 months	9.7 (7.8–12.0)	13.1 (8.7–19.6)	8.5 (5.6–12.8)	6.8 (4.0–11.4)
	1 year	4.7 (4.0–5.4)	5.4 (4.1–7.0)	3.5 (2.6–4.5)	4.3 (3.0–6.2)
	5 years	3.2 (2.9–3.6)	3.6 (3.0–4.4)	2.9 (2.4–3.6)	4.0 (2.9–5.5)
Pulmonary embolism	3 months	9.0 (6.4–12.5)	11.8 (5.7–24.3)	7.4 (4.2–13.2)	8.1 (3.7–17.9)
	1 year	5.3 (4.2–6.6)	5.8 (3.8–8.8)	4.1 (2.8–6.1)	5.5 (3.1–9.7)
	5 years	3.4 (2.8–4.1)	3.5 (2.5–4.9)	3.2 (2.4–4.4)	4.9 (3.1–7.7)
Deep venous thrombosis	3 months	7.3 (5.2–10.3)	9.9 (5.5–17.8)	7.4 (4.0–13.8)	5.2 (2.4–11.1)
	1 year	3.7 (3.0–4.6)	4.6 (3.1–6.7)	3.0 (2.0–4.4)	3.8 (2.2–6.6)
	5 years	3.3 (2.8–3.9)	4.5 (3.4–5.9)	2.5 (1.9–3.3)	3.6 (2.3–5.8)

HR=hazard ratio, CI=confidence interval, MPN=myeloproliferative neoplasm, PV=polycythemia vera, ET=essential thrombocythemia, PMF=primary myelofibrosis