Vessel density (VD) and perfusion density (PD) measurements and diabetic retinopathy (DR) grade, after adjusting for age, gender, signal strength index (SSI), axial length and duration of diabetes mellitus disease. Top: VD (left) and PD (right) measurements in the complete scanned area using the 3 × 3 mm scanning protocol. Bottom: VD (left) and PD (right) measurements in the complete scanned area using the 6 × 6 mm scanning protocol. Generalized Estimating Equation (GEE) adjusted for age, gender, signal strength index (SSI), axial length, and duration of diabetes mellitus disease for global P value; pairwise comparisons by Kruskal-Wallis test with Bonferroni correction. P < 0.05: (a) vs. Control; (b) vs. No DR; (c) vs. Mild DR; (d) vs. Moderate DR; (e) vs. Severe DR; (f) vs Proliferative DR (Total number of eyes [3 × 3/6 × 6]: control 189/183, no DR 504/503, mild NPDR 202/198, moderate NPDR 29/30, severe NPDR 4/3, PDR 10/10).