Table 2.
Influence of Diabetes Mellitus Duration on Optical Coherence Tomography Angiography (OCTA) Metrics
| Diabetes Mellitus Duration | ||||||
|---|---|---|---|---|---|---|
| 3 × 3mm OCTA | Statistic | Total (N = 605) | < 5 y (N = 49) | 5-15 y (N = 165) | ≥ 15 y (N = 391) | P Valuea |
| Vessel density (mm-1) | Mean (SD) | 19.8 (1.9) | 20.8 (1.5) | 20.7 (1.5) | 19.3 (1.9) | < 0.001b |
| Median (IQR) | 20 (18.7; 21.2) | 20.8 (19.9; 22) | 21 (20; 21.8) | 19.5 (18.2; 20.6) | ||
| Perfusion density | Mean (SD) | 0.36 (0.03) | 0.37 (0.02) | 0.37 (0.03) | 0.36 (0.03) | < 0.001b |
| Median (IQR) | 0.37 (0.35; 0.38) | 0.38 (0.36; 0.39) | 0.38 (0.36; 0.39) | 0.36 (0.34; 0.38) | ||
| Area (mm2) | Mean (SD) | 0.24 (0.1) | 0.24 (0.08) | 0.23 (0.1) | 0.24 (0.1) | 0.523 |
| Median (IQR) | 0.23 (0.17; 0.3) | 0.24 (0.17; 0.29) | 0.22 (0.17; 0.28) | 0.23 (0.17; 0.31) | ||
| Perimeter (mm) | Mean (SD) | 2.08 (0.5) | 2.1 (0.38) | 2.01 (0.47) | 2.11 (0.53) | 0.146 |
| Median (IQR) | 2.09 (1.79; 2.4) | 2.07 (1.86; 2.4) | 2.01 (1.77; 2.4) | 2.16 (1.79; 2.5) | ||
| Circularity | Mean (SD) | 0.65 (0.09) | 0.67 (0.08) | 0.67 (0.07) | 0.64 (0.09) | 0.001 b |
| Median (IQR) | 0.66 (0.6; 0.71) | 0.68 (0.62; 0.74) | 0.67 (0.62; 0.72) | 0.65 (0.58; 0.7) | ||
| 6 × 6mm OCTA | Statistic | Total (N = 598) | Diabetes Mellitus Duration | P Valuea | ||
| < 5 y (N = 49) | 5-15 y (N = 161) | ≥ 15 y (N = 388) | ||||
| Vessel density (mm-1) | Mean (SD) | 17.6 (1.3) | 18.1 (1.2) | 18 (1.2) | 17.3 (1.4) | < 0.001b |
| Median (IQR) | 17.9 (16.9; 18.6) | 18.5 (17.7; 18.9) | 18.3 (17.7; 18.8) | 17.6 (16.6; 18.3) | ||
| Perfusion density | Mean (SD) | 0.43 (0.04) | 0.44 (0.03) | 0.44 (0.03) | 0.43 (0.04) | < 0.001b |
| Median (IQR) | 0.45 (0.42; 0.46) | 0.45 (0.44; 0.46) | 0.45 (0.43; 0.46) | 0.44 (0.41; 0.46) | ||
| Area (mm2) | Mean (SD) | 0.24 (0.1) | 0.24 (0.09) | 0.23 (0.09) | 0.24 (0.11) | 0.541 |
| Median (IQR) | 0.23 (0.16; 0.3) | 0.24 (0.18; 0.29) | 0.22 (0.17; 0.29) | 0.23 (0.16; 0.3) | ||
| Perimeter (mm) | Mean (SD) | 1.96 (0.48) | 1.96 (0.4) | 1.94 (0.43) | 1.97 (0.51) | 0.537 |
| Median (IQR) | 1.97 (1.66; 2.3) | 2 (1.71; 2.2) | 1.89 (1.67; 2.2) | 1.98 (1.64; 2.3) | ||
| Circularity | Mean (SD) | 0.73 (0.08) | 0.76 (0.07) | 0.74 (0.08) | 0.73 (0.08) | 0.016 |
| Median (IQR) | 0.75 (0.69; 0.79) | 0.77 (0.73; 0.82) | 0.75 (0.69; 0.8) | 0.74 (0.69; 0.79) | ||
SD, indicates standard deviation; IQR, interquartile range.
a
Generalized Estimating Equation (GEE). Unadjusted P value.
b
Generalized Estimating Equation (GEE). Adjusted P value < 0.05 (adjusted for age, gender, signal strength index (SSI), axial length, and diabetic retinopathy stage).