Table 3.

Selection of Relevant Papers Published to Date on OCTA and Diabetes Mellitus (n ≥ 25), Ordered by Diabetes Mellitus Type, Sample Size, and Publication Year

			Study Eyes
		Type of		Type 1	Type 2		OCTA	Vascular	OCTA
Author	Year	Diabetes	Total	DM	DM	Controls	Parameter	Plexus	Device	Software
Carnevali et al.24	2017	1	50	25	–	25	VD, FAZ	S, D, CC	Cirrus Angioplex	Custom - Image J
Sacconi et al.25	2019	1	61	34	–	27	PD, FAZ	S, D, CC	PLEX Elite 9000	Built in
Li et al.26	2019	1	91	47 (children)	–	44	VD, PD, FAZ	S	Cirrus Angioplex	Built in
Mameli et al.29	2019	1	94	53 (children)	–	41	VD	S, D	RTVue XR Avanti	Built in
Inanc et al.30	2019	1	117	60 (children)	–	57	VD, PD, FAZ	S, D	RTVue XR Avanti	Built in
Niestrata-Ortiz et al.28	2019	1	142	112 (children)	–	30	FAZ	S, D	DRI OCT-A Triton	Built in
Golebiewska et al.27	2017	1	248	188 (children)	–	60	VD, FAZ	S, D	RTVue XR Avanti	Built in
Dimitrova et al.34	2017	Both	62	?	29	33	VD, FAZ	S, D, CC	RTVue XR Avanti	Built in
Lupidi et al.11	2017	Both	95	?	48	47	VD, PD, FAZ	S, D	Spectralis OCT2	Built in
Gozlan et al.23	2017	Both	58	9	49	-	PD, FAZ,	S, D	RTVue XR Avanti	Built in
De Carlo et al.35	2015	Both	82	?	61	21	MA, PD, FAZ	Undisclosed	RTVue XR Avanti	Built in
Vujosevic et al.16	2018	Both	117	?	83	34	VD, PD	S	DRI OCT-A Triton Plus	Custom - Image J
Vujosevic et al.21	2019	Both	111	38	55	18	VD, PD, FAZ	S, D	DRI OCT-A Triton	Custom - Image J
Rodrigues et al.22	2019	Both	101	18	83	-	VD, FAZ	S, D, CC	Angiovue System	Built in
Choi et al.12	2017	Both	152	?	89	63	VD, FAZ	S, M, D, CC	UHS-SSOCT (MIT, NEEC)	Research prototype
Rosen et al.17	2019	Both	153	9	104	40	PD, FAZ	S, D	RTVue XR Avanti	Built in
Nesper et al.37	2017	Both	181	?	137	44	VD, PD, FAZ	S, D, CC	RTVue XR Avanti	Built in
Tang et al.13	2017	Both	434	?	434	–	VD, FD, FAZ	S	DRI OCT-A Triton	Built in
Tang et al.41	2019	Both	447	?	447	–	VD, FAZ	S	DRI OCT-A Triton	Custom - MatLab
Ishibazawa et al.4	2015	Undisclosed	47	?	47	–	MA, PD	S, D	RTVue XR Avanti	Built in
Shen et al.18	2018	Undisclosed	90	?	49	41	VD	S	RTVue XR Avanti	Built in
Samara et al.42	2017	Undisclosed	118	?	84	34	VD, FAZ	S, D	RTVue XR Avanti	Built in
Mastropasqua et al.19	2019	Undisclosed	119	?	94	25	VD, PD	S, D, CC	PLEX Elite 9000	Built in
Conti et al.14	2018	Undisclosed	136	?	99	37	PD, FAZ	S, D, CC	RTVue XR Avanti	Built in
Onishi et al.15	2018	Undisclosed	180	?	136	44	VD, PD	S, M, D	RTVue XR Avanti	Built in
Yang et al.20	2019	Undisclosed	282	?	239	43	VD	CC	RTVue XR Avanti	Built in
Cao et al.7	2018	2	138	–	71	67	VD, PD, FAZ	S, D, CC	RTVue XR Avanti	Built in
Ting et al.8	2017	2	100	–	100	0	VD, FD	S, D	DRI OCT-A Triton	Built in
Tan et al.43	2019	2	212	–	126	86	VD	S, D	RTVue XR Avanti	Built in
Zeng et al.9	2019	2	170	–	137	33	VD	S, D	RTVue XR Avanti	Built in
Kim et al.10	2018	2	155	–	155	0	VD, PD, FAZ	S, D	Cirrus Angioplex	Custom - Image J
This study	2020	1	1186	956	–	230	VD, PD, FAZ	S	CirrusAngioplex	Built in

OCTA, optical coherence tomography angiography; DM, diabetes mellitus; VD, vessel density; PD, perfusion density; FAZ, foveal avascular zone; S, superficial; M, medium; D, deep; CC, choriocapillaris; RS, research software.

Note: The OCTA parameters may not have been described in the original papers exactly as those described in the table, as the terms have been unified for comparison purposes. Devices: Cirrus Angioplex, Carl Zeiss Meditec, Dublin, CA; PLEX Elite 9000, Carl Zeiss Meditec, Inc., Dublin, CA; RTVue XR Avanti, Optovue, Inc., Fremont, CA; Angiovue System, Optovue Inc., Fremont, CA; DRI OCT-A Triton Plus, Topcon Europe, Milano; Spectralis OCT2, Heidelberg Engineering, Heidelberg. (*= see “References” section).