Table 5.

Primary outcomes of retained studies

Cardiovascular diseases
Outcome 1 No relationship	Outcome 2 Possible relationship (mixed results)	Outcome 3 Positive relationship
Schmitt et al. 2015 (arterial stiffness) Li et al. 2017 (CV event) Ioannidou et al. 2006 (CRP)	Texeira de Freitas et al. 2012 (hsCRP) Paraskevas et al. 2008 (hsCRP)	Orlandi et al. 2014 (for endothelial function) Teeuw et al. 2014  (numerous surrogates:  hsCRP in those with comorbidities; and improved endothelial function)