Fig. 1.

Memory deficit of rats with amyloid-β infusion. Ratio of the right turns in Y maze (A), latency time to enter the dark room in passive avoidance test at 3 trials (B), the latency time to locate zone with the platform and the period to stay in the platform zone on day 5 during the water maze test (C) were shown. The amyloid-β(25–35) infused diabetic rats AD model rats received assigned diet for 8 weeks as follows: 1) a normal diet (28 energy % fat diet) with ad libitum feeding (AD-CON), 2) ketogenic diet (AD-KD; 0.1% carbohydrate diet), 3) high carbohydrate diet (AD-CHO; 68 energy % carbohydrate diet) and 4) normal diet with intermittent fasting (AD-IMF). The sham-operated rats received the same diet (normal diet) as AD-CON (Non-AD-CON) for 8 weeks. Each dot and bar represents means ± SD (n = 10). *Significantly different among the groups by one-way-ANOVA at p<0.05. ^a,b,c,dDifferent letters on the bars indicate significant differences by Tukey test at p<0.05.