Fig. 4.

Changes in the serum glucose levels during an intraperitoneal insulin tolerance test (IPITT). An IPITT was conducted by intraperitoneally injecting insulin (1 U/kg body weight) after a 6 h fast. The serum glucose levels (A) and area under the curve of serum glucose levels (B) were measured. The amyloid-β(25–35) infused diabetic rats AD model rats received assigned diet for 8 weeks as follows: 1) a normal diet (28 energy % fat diet) with ad libitum feeding (AD-CON), 2) ketogenic diet (AD-KD; 0.1% carbohydrate diet), 3) high carbohydrate diet (AD-CHO; 68 energy % carbohydrate diet) and 4) normal diet with intermittent fasting (AD-IMF). The sham-operated rats received the same diet (normal diet) as AD-CON (Non-AD-CON) for 8 weeks. Each dot and bar represents means ± SD (n = 10). *Significantly different among the groups by one-way-ANOVA at p<0.05. ^a,b,c,dDifferent letters on the bars indicate significant differences by Tukey test at p<0.05.