Table 2.
AD-CON (n = 10) | AD-KD (n = 10) | AD-IMF (n = 10) | AD-CHO (n = 10) | Non-AD-CON (n = 10) | |
---|---|---|---|---|---|
Final body weight (g) | 366 ± 27ab | 353 ± 32b | 291 ± 27d | 317 ± 26c | 373 ± 15a |
Body weight gain (g) | 169 ± 12a | 165 ± 15a | 94.4 ± 8.4c | 117 ± 14b | 175 ± 9.2a |
Epididymal fat pads/body weight (g/kg body weight) | 11.3 ± 1.0a | 11.0 ± 0.7a | 9.9 ± 0.5b | 10.1 ± 0.8b | 11.0 ± 1.0a |
Retroperitoneal fat/body weight (g/kg body weight) | 11.1 ± 0.7a | 11.3 ± 0.9a | 9.8 ± 0.9b | 9.2 ± 0.7b | 11.1 ± 1.0a |
Visceral fat (g/kg body weight) | 22.4 ± 1.6a | 22.3 ± 1.4a | 19.7 ± 1.1b | 19.3 ± 1.7b | 22.1 ± 1.9a |
Food intake (g/day) | 16.6 ± 1.8a | 9.7 ± 1.0b | 10.3 ± 2.1b | 15.8 ± 1.7a | 16.7 ± 1.6a |
Energy intake (kcal/day) | 71.3 ± 7.7a | 63.8 ± 6.6b | 44.4 ± 9.0c | 61.5 ± 6.6b | 71.6 ± 6.9a |
Energy expenditure (kcal/body weight/day) | 103 ± 10ab | 110 ± 11a | 117 ± 12a | 110 ± 11a | 94 ± 11b |
Respiratory quotient | 0.86 ± 0.09ab | 0.81 ± 0.09b | 0.82 ± 0.09b | 0.92 ± 0.08a | 0.81 ± 0.08b |
Carbohydrate oxidation during dark cycle (mg/kg body weight/min) | 5.8 ± 0.7b | 4.1 ± 0.7c | 4.7 ± 0.7c | 8.7 ± 0.9a | 3.5 ± 0.5d |
Fat oxidation during dark cycle (mg/kg body weight/min) | 5.2 ± 0.6c | 7.6 ± 0.8a | 7.8 ± 0.9a | 3.0 ± 0.4d | 6.5 ± 0.8b |
The amyloid-β(25–35) infused diabetic rats AD model rats received assigned diet for 8 weeks as follows: 1) a normal diet (28 energy % fat diet) with ad libitum feeding (AD-CON), 2) ketogenic diet (AD-KD; 0.1% carbohydrate diet), 3) high carbohydrate diet (AD-CHO; 68 energy % carbohydrate diet) and 4) normal diet with intermittent fasting (AD-IMF). The sham-operated rats received the same diet (normal diet) as AD-CON (Non-AD-CON) for 8 weeks. Values represent means ± SD. a,b,c,dDifferent superscripts after SD indicate significant differences at p<0.05.