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. 2020 Sep 29;33(13):966–997. doi: 10.1089/ars.2020.8024

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© Katarína Smolková et al. 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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FIG. 5. — Genetic aberrations of NRF2 signaling pathway members in breast carcinoma. (A) Chart depicting percentages of mutations and copy number variations (amplification and deletion, respectively) of NRF2, KEAP1, CUL3, and several genes involved in noncanonical activation of NRF2 as discussed in the Strategic role of p62 in NRF2 signaling: autophagy and metabolic rewiring section. The data are based on the TCGA portal search (data set TCGA BRCA, Ductal and Lobular Neoplasms, containing 513 cases). (B) Mutation maps (lollipop plots) depicting positions of the mutations in NRF2 (NFE2L2), KEAP1, and CUL3 proteins. The data are based on a cBIOPORTAL search, combining several studies containing data on breast carcinoma samples. Color images are available online.