Table 3.

Quantification of Type I Collagen by Means of ELISA, After 24, 48 and 72 h of Treatment with Different Doses of HA (A) and PLLA (B) Compared with the Control Group

Group/Hours	24	48	72
(A)
Control	15.59±0.46A,a	18.26±1.39A,b	16.16±2.89A,a
0.5 mg/mL	28.90±1.10B,a	26.86±1.08B,a	27.45±0.94B,a
1 mg/mL	27.76±1.13B,a	26.94±1.26B,a	25.02±1.19C,a
5 mg/mL	24.95±0.67C,a	27.22±0.44B,b	22.82±0.87D,c
10 mg/mL	24.24±0.86C,a	26.96±0.81B,b	21.53±1.60D,c
(B)
Control	15.59±0.46A,a	18.26±1.39A,a	16.16±2.89A,a
0.05 mg/mL	21.09±1.86B,a	26.43±1.28B,b	25.10±1.23B,b
0.1 mg/mL	21.51±1.37B,a	28.78±1.19B,b	28.34±1.16B,b
0.5 mg/mL	23.15±1.66B,C,a	26.07±2.89B,b	27.73±2.55B,b
1 mg/mL	25.30±0.63C,D,a	29.64±1.20B,b,c	27.44±0.75B,a,c

Notes: Different capital letters represent significant differences among groups, for each experimental time. Different lowercase letters indicate significant differences at different times. The results were expressed as pg/ml. Data were reported as the mean ± SD.