(A‐C) Patients with PD experiencing increased stress level during lockdown had worse NMSS (*P = 0.012) and Hospital Anxiety and Depression Scale–Anxiety (*P = 0.006) scores. The patients' feature associated with higher levels of stress in caregivers was worse NMSS score (*P = 0.018). The UPDRS‐II score was not associated with higher stress levels in patients with PD or caregivers. (D) Worsening of stress occurred in caregivers of PD patients scoring higher at cardiovascular, mood/cognition, urinary, and miscellaneous domains of the NMSS (*P < 0.05). (E) PD patients with increased stress had significant worse mood/cognition score of NMSS (*P < 0.05). PD, Parkinson's disease; NMSS, Non‐Motor Symptoms Scale; SCOPA‐PC, Scales for Outcomes in Parkinson's Disease–Psychiatric Complications; UPDRS‐II, Unified Parkinson's Disease Rating Scale Part II.