Table 4.

The Functional Analyses of Target Genes for Differentially Expressed miRNAs in NPC.

Category	Term	Count	P-value	Genes
GOTERM_BP (top 5)	DNA replication	36	1.46E-10	SLBP, PRIM2, PCNA, RRM1, RRM2, CDC7, CDC6, DNA2, DTL, MCM2,,,,,,
	cellular process	498	6.77E-10	MAPKBP1, MYC, SOX11, HMGA2, ITGA9, CXCL9, CAD, IFNG, TERF2IP, NDUFS2,,,,,,
	nucleic acid metabolic process	121	4.85E-09	CCNT1, MPG, DSCC1, YARS2, NARS, ZFP36, PTTG1, SNRPD1, CHEK1, NARS2,,,,,,
	DNA metabolic process	60	4.85E-09	MPG, DSCC1, CHAF1A, SUMO1, PTTG1, CHEK1, PIM1, DNMT3B, TK1, KPNA2,,,,,,
	macromolecule biosynthetic process	96	4.85E-09	BMPR2, CCNT1, TUSC3, DSCC1, YBX1, MED16, FOXM1, TRAM2, YARS2, NARS,,,,,,
GOTERM_CC (top 5)	membrane-enclosed lumen	151	3.02E-17	SPARC, MYC, CHEK2, CHEK1, NARS2, PIM1, OIP5, KPNA2, PHLDA1, PDK2,,,,,,
	intracellular part	556	1.06E-16	ATP5C1, GABPB1, ELK3, MPRIP, MYC, DPYSL2, AKT3, NAMPT, STMN1, RPL37|HOXA7, RKACB,,,,,,
	organelle lumen	146	1.57E-16	SPARC, CCNT1, MPG, DSCC1, MYC, CHEK2, CHEK1, NARS2, PIM1, OIP5,,,,,,
	intracellular organelle lumen	143	2.88E-16	CCNT1, MPG, DSCC1, GMNN, GOLIM4, ATP5C1, YARS2, SNRPD1, MYC, CHEK2,,,,,,
	intracellular	566	2.97E-16	ATP5C1, GABPB1, ELK3, MPRIP, MYC, DPYSL2, AKT3, NAMPT, STMN1, RPL37,,,,,,
GOTERM_MF (top 5)	protein binding	473	8.16E-20	MAPKBP1, SERPINE1, GABPB1, ELK3, MPRIP, MYC, HMGA2, ISG15, NUP153, POU2F3,,,,,,
	binding	596	3.60E-08	MAPKBP1, SERPINE1, MYC, HMGA2, ISG15, NUP153, POU2F3, IGF2 R, SMAD7, BMP2,,,,,,
	platelet-derived growth factor binding	5	1.26E-02	PDGFRA, COL3A1, COL1A2, COL5A1, COL4A1
	ATP binding	94	1.26E-02	ERCC6 L, BMPR2, CHD7, OLA1, KIF11, PIK3C2A, PKD2, YARS2, OASL, IFIH1,,,,,,
	adenyl ribonucleotide binding	95	1.26E-02	ERCC6 L, BMPR2, CHD7, OLA1, KIF11, PIK3C2A, PKD2, YARS2, IFIH1, NARS,,,,,,

GO, Gene ontology; BP, biological process; MF, molecular function; CC, cellular component; NPC, nasopharyngeal carcinoma