Table 2.

The Results of P-syn in Skin Autonomic Structures in Thick and Thin Skin Sections From Subjects With PD.

N=29	Sweat Gland			Pili Muscle			Blood Vessel
Thickness (µm)	50	20	10	50	20	10	50	20	10
Number of P-syn-positive PD subjects by structurea	21	20	14	24	14	19	26	21	19
Percentage of positive PD subjects by structure	72	69	48	82	48	65	89	72	65
Rate of P-synb	0.53 ± 0.4	0.3 ± 0.28	0.25 ± 0.33	0.57 ± 0.38	0.16 ± 0.21	0.23 ± 0.25	0.68 ± 0.33	0.35 ± 0.32	0.31 ± 0.32
p value (vs 50 µm)		<0.05	<0.01		<0.01	<0.01		<0.01	<0.01
Overall P-syn resultc	100% in 50 µm, 90% in 20 µm, and 73% in 10 µm sections

Abbreviations: P-syn, phosphorylated alpha-synuclein; PD, Parkinson’s disease.

^aNumber of P-syn-positive PD subjects by structure: The number of individuals with one or more positive autonomic structures (sweat gland, pili muscle, blood vessel) in any of the three biopsies.

^bRate of P-syn: P-syn-positive structures divided by total structures in the three biopsies of each individual (mean and SD).

^cOverall P-syn result: The number of individuals who were found to have P-syn-positive autonomic structures SG, PM, or BV in any of the three skin biopsies.