Figure 2:

(A) Study schema (n=114 individuals). 64.9% (n=74) of the cohort had either a vascular aneurysm or event (n=26) or a structural cardiac anomaly (n=48). Twenty-one had a thoracic aortic aneurysm (TAA), with 4/21 patients having both a TAA and a dilated pulmonary artery. One patient with a dilated pulmonary artery alone was not specifically depicted in schema. (B) Frequency of the vascular and structural cardiac abnormalities in individuals. TAA and PDAs were very common in subjects and frequently occurred in conjunction. (C) Gender distribution of cardiovascular malformations and aneurysms: There was no significant difference between males and females, by Fisher’s exact test. Absolute numbers are in parentheses. M = male, F = female. No CVD = No cardiovascular anomalies or abnormalities, TAA = Thoracic aortic aneurysm, SCM= Structural cardiovascular malformation, Vasc = Vascular event (i.e. stroke, myocardial infarction).

ASD = Atrial septal defect, AV= Aortic valve abnormality, MV= Mitral valve abnormality, PAD = Pulmonary artery dilatation, PDA = Patent ductus arteriosus, PV = Pulmonary valve abnormality, TV= Tricuspid valve abnormality, VSD = Ventricular septal defect.