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. 2020 May 28;29(11):3424–3454. doi: 10.1177/0962280220921889

Table 1.

Estimates from the Cox model, the fixed effects model, the gamma and log-normal frailty models.

Cox model
Fixed Effects
Gamma frailty
Log-normal frailty
Coef SE Robust SE Coef SE Coef SE Coef SE
Type of surgery Mastectomy with RT
Mastectomy without RT 0.25 0.11 0.17 0.16 0.13 0.16 0.12 0.16 0.12
Breast conserving −0.07 0.10 0.10 −0.09 0.10 −0.08 0.10 −0.08 0.10
Tumor size <2 cm
2–5 cm 0.35 0.10 0.10 0.35 0.10 0.35 0.10 0.35 0.10
>5 cm 0.89 0.15 0.16 0.83 0.16 0.84 0.16 0.84 0.16
Nodal status Node negative
Node positive 0.97 0.11 0.26 0.77 0.11 0.79 0.11 0.78 0.11
Age 50
>50 0.01 0.10 0.12 0.10 0.10 0.09 0.10 0.09 0.10
Adjuvant chemo No
Yes −0.38 0.13 0.35 −0.15 0.14 −0.17 0.13 −0.17 0.14
Tamoxifen No
Yes −0.17 0.12 0.31 0.12 0.13 0.08 0.12 0.08 0.12
Perioperative chemo No
Yes −0.12 0.07 0.06 −0.13 0.07 −0.13 0.07 −0.13 0.07
Frailty variance 0.122 0.132

Note: Estimated center effects of the fixed effects model have been omitted from the table.