Table 3.
The effect of β-sitosterol on the paw edema of CFA-induced arthritic rats.
| S. No | Groups | Increase in
Joint diameter (cm) (days) |
|||
|---|---|---|---|---|---|
| Day 7 | Day 14 | Day 21 | Day 28 | ||
| 1 | CFA | 2.8 ± 0.43 | 3.1 ± 0.78 | 3.7 ± 0.69 | 3.5 ± 0.72 |
| 2 | CFA+ β-sitosterol (2.5 mg/kg) | 2.1 ± 0.72* | 2.5 ± 0.83** | 2.4 ± 0.74*** | 2.2 ± 0.89*** |
| 3 | CFA+ β-sitosterol (25 mg/kg) | 2 ± 0.84** | 2.1 ± 0.45*** | 1.9 ± 0.45*** | 1.4 ± 0.93*** |
| 4 | CFA+ β-sitosterol-SLN | 1.4 ± 0.83*** | 1.2 ± 0.35*** | 0.82 ± 0.09*** | 0.43 ± 0.07*** |
| 5 | CFA + Indomethacin (400µg/kg) | 1.5 ± 0.34*** | 1.6 ± 0.34*** | 1.1 ± 0.63*** | 0.8 ± 0.05*** |
All values are presented as mean ± SEM. Statisticalanalysis by one-way ANOVA followed by Dunnett’s multiple comparison. *p < .05, **p < .01 and ***p < .01 vs. Control.