Table 1.

Cytotoxicity of the selected compounds against some human cancer cell lines.

Cpd code	R	MW	Cytotoxicity (IC50a, µM)/cell linesb
			SW620	PC3	NCI-H23
4a	H	387.87	2.09 ± 0.138	2.97 ± 0.017	1.67 ± 0.056
4b	2-Cl	422.31	0.16 ± 0.002	0.16 ± 0.006	0.12 ± 0.002
4c	3-Cl	422.31	5.25 ± 0.059	4.70 ± 0.145	4.81 ± 0.098
4d	4-Cl	422.31	0.002 ± 0.000	0.002 ± 0.000	0.001 ± 0.000
4e	2,6-Cl2	456.75	>10	>10	>10
4f	4-NO2	432.86	0.011 ± 0.001	0.010 ± 0.000	0.005 ± 0.001
4g	2-OH	403.87	0.62 ± 0.003	0.58 ± 0.014	0.69 ± 0.017
4h	2-OH-3-allyl	443.93	0.58 ± 0.000	0.61 ± 0.003	0.56 ± 0.000
4i	2-OH-4-OCH3	433.89	0.80 ± 0.042	0.83 ± 0.020	0.62 ± 0.029
4j	3-OH-4-OCH3	433.89	5.00 ± 0.065	7.31 ± 0.423	6.60 ± 0.407
4k	4-OCH3	417.89	2.53 ± 0.055	3.29 ± 0.023	2.45 ± 0.028
4l	4-N(CH3)2	430.94	>10	>10	>10
4m	3,4,5-(OCH3)3	477.94	>10	>10	>10
5a	H	428.88	1.96 ± 0.055	1.54 ± 0.020	1.71 ± 0.044
5b	5-F	446.87	2.28 ± 0.084	1.58 ± 0.012	1.71 ± 0.040
5c	5-Cl	463.32	4.33 ± 0.223	4.46 ± 0.039	3.83 ± 0.247
5d	7-Cl	463.32	4.49 ± 0.203	3.74 ± 0.142	2.68 ± 0.225
5e	5-Br	507.77	1.70 ± 0.051	1.61 ± 0.022	1.17 ± 0.076
5f	5-CH3	442.90	7.56 ± 0.200	4.71 ± 0.006	5.13 ± 0.382
5g	5-OCH3	458.90	5.27 ± 0.192	3.79 ± 0.180	3.86 ± 0.076
5-FUc		130.08	8.84 ± 1.92	13.61 ± 0.46	13.45 ± 3.92
PAC-1d		392.49	4.57 ± 0.17	4.23 ± 0.45	5.11 ± 0.07
Oncrasin-1e		269.06	3.17 ± 0.24	3.11 ± 0.28	3.32 ± 0.31

^aThe concentration (µM) of compounds that produces a 50% reduction in cell growth, the numbers represent the averaged results from triplicate experiments with deviation of less than 10%.

^bCell lines: SW620, colon cancer; PC3, prostate cancer; NCI-H23, lung cancer.

^c5-FU: 5-fluorouracil, a positive control.

^dPAC-1: a positive control.

^eOncrasin-1: a positive control.