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. 2020 Sep 14;27(1):1308–1318. doi: 10.1080/10717544.2020.1818880

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — RJ EVs released from collagen gels promote HdnF migration and decrease proliferation; (A) Quantitative analysis of scratch closure (4, 8, 12, and 24 h); fibroblasts colocalized with collagen gels with and without RJ EVs compared to ctrl; data displayed as percentage scratch closure compared to 0 h; (B) Representative phase contrast micrographs at time point 0 h and 24 h; (C) Schematic representation of the experimental setup: fibroblasts were preconditioned for 24 h with RJ EVs released from collagen gels, subsequently a scratch was inflicted and cellular migration was assessed after 4, 8, 12, and 24 h; (D) Scratch closure of collagen gels with (dark gray) and without (light gray) RJ EVs after 24 h, as percentage of migration ctrl; (E) proliferation of HdnF evaluated with BrdU assay in presence of collagen gels with (dark gray) and without RJ EVs (light gray), measured at 450 nm; data displayed as percentage of control; A, C: n = 4; E: n = 5; mean ± SD; statistics described in methods.