Table 3.
Prevalence of species significantly different between DD and DH sites at baseline.
| BL |
3 M |
6 M |
12 M† |
18 M† |
24 M† |
||||
|---|---|---|---|---|---|---|---|---|---|
| ProbeID | DD | DH | DD | DH | DD | DH | DD | DD | DD |
| Aggregatibacter actinomycetemcomitans HOT-531_m | 81%*** | 17% | 6.25%+++ | 0% | 25%+++ | 0% | 3%+++ | 0%+++ | 0%+++ |
| Campylobacter gracilis HOT-623_m | 92%* | 78% | 75%+ | 81% | 75%+++ | 83% | 67%++ | 48%+++ | 52%+++ |
| Neisseria Cluster II HOT-014/609/682/764 | 64% | 58% | 62% | 62% | 61% | 17% | 50% | 24% | 16% |
| Tannerella forsythia HOT-613 | 52%* | 31% | 21%+ | 14% | 61% | 42% | 33% | 14%++ | 19%++ |
| Filifactor alocis HOT-539_m | 47%* | 22% | 18%*++ | 0%+ | 39% | 8% | 10%+++ | 5%+++ | 3%+++ |
| Haemophilus sp clone HOT-036_m | 43%*** | 8% | 13%++ | 14% | 32% | 17% | 17%+ | 10%++ | 3%+++ |
| Selenomonas infelix and sp clones HOT-126/479/481/639_m | 43% | 61% | 43% | 52% | 39% | 58% | 29% | 24% | 3% |
| Prevotella intermedia HOT-643_m | 20%* | 6% | 0%+ | 0% | 11% | 0% | 3%+ | 0%+ | 0%++ |
| Treponema lecithinolyticum HOT-653_m | 20%* | 6% | 13% | 5% | 21% | 0% | 0%++ | 10% | 6% |
| Eubacterium[11][G 5] saphenum HOT-759 | 18%** | 0% | 9% | 5% | 4% | 0% | 7% | 10% | 0%+ |
| Streptococcus oralis and sp clones HOT-064/707 | 77% | 94%* | 88% | 100% | 89% | 100% | 97%+ | 90% | 94% |
| Parvimonas micra HOT-111_m | 60% | 80%* | 75% | 76% | 79% | 58% | 73% | 67% | 71% |
| Streptococcus anginosus and gordonii HOT-543/622_m | 43% | 69%* | 78%+ | 95%+ | 68%+ | 83% | 77%++ | 76%+ | 81%++ |
| Eubacterium[11][G 7] yurii HOT-377_m | 40% | 80%*** | 53% | 43%++ | 39% | 42%+ | 47% | 43% | 39% |
| Capnocytophaga sp HOT-335_m | 38% | 75%*** | 44% | 19%+ | 25% | 42%+ | 10%++ | 0%++ | 6%++ |
| Selenomonas sp clones HOT-138/146_m | 23% | 47%* | 31% | 38% | 11% | 33% | 13% | 5% | 6% |
| Selenomonas noxia and sp clone HOT-130/140 | 19% | 38%* | 41%+ | 38% | 14% | 58%** | 17% | 14% | 19% |
| Aggregatibacter segnis and sp clone HOT-512/62_m | 11% | 33%* | 31%+ | 33% | 7% | 8% | 7% | 5% | 6% |
| Streptococcus sp strains HOT-070/071 | 11% | 30%* | 34%+ | 57% | 36%++ | 33% | 27% | 24% | 26% |
| Veillonella sp clones HOT-780 | 8% | 25%* | 18% | 52%*+ | 11% | 41%* | 3% | 10% | 19% |
| Slackia exigua HOT-602_m | 6% | 33%** | 16% | 14% | 11% | 17% | 0% | 0% | 0% |
| Prevotella denticola HOT-291 | 4% | 22%** | 38%+ | 19% | 7% | 33%* | 13% | 5% | 16% |
| Prevotella melaninogenica and sp clone BE073 HOT-298/469 | 2% | 27%*** | 6%* | 28%* | 4% | 25%* | 3% | 5% | 3% |
| Rothia dentocariosa and mucilaginosa HOT-587/681 | 2% | 19%** | 28%+ | 48%+ | 21%++ | 50%+ | 40%+++ | 33%+++ | 32%+++ |
| Selenomonas flueggei HOT-125_m | 2% | 16%* | 16%+ | 24% | 0% | 8% | 3% | 5% | 0% |
| Streptococcus parasanguis I and II and sp clone HOT-057/411/721 | 2% | 13%* | 13%+ | 29% | 21%++ | 25% | 27%+++ | 19%++ | 19%++ |
| Clostridiales[F 2][G 1] sp clone HOT-075 | 0% | 8%* | 3% | 14% | 0% | 0% | 0% | 0% | 0% |
| Neisseria gonorrhoeae and polysaccharea HOT-621/737 | 0% | 8%* | 3% | 10% | 7% | 8% | 0% | 0% | 0% |
| Prevotella oulora HOT-288_m | 0% | 11%* | 15%*+ | 42%*++ | 4% | 41%**+ | 0% | 0% | 13%++ |
*P < 0.05, **P < 0.01, ***P < 0.001 between DD (diseased sites in C/MIP) and DH (healthy sites in C/MIP)
+P < 0.05, ++P < 0.01, +++P < 0.001 compared to baseline within same group
†DH sites from 12 M, 18 M, and 24 M yielded too little material for HOMIM analysis