Table 1.
Antimicrobial activity of curcumin, piperine and curcumin – piperine – 2-hydroxypropyl-β-cyclodextrin system in the concentration 25 mg/mL when dissolved in methanol and filtered.
| Microorganism | Inhibition zone (mm) – Agar well diffusion technique |
|||
|---|---|---|---|---|
| Curcumin |
Piperine |
Curcumin + Piperine + HP-β-CD (ph. m.) |
Curcumin – Piperine – HP-β-CD (kneading) |
|
| 25 mg/mL | 25 mg/mL | 25 mg/mL | 25 mg/mL | |
| C. difficile ATCC 9689 | 6.5 | 3.5 | 3.5 | 5.5 |
| C. butyricum ATTC 860 | 5.5 | 5.5 | 4.0 | 7.0 |
| L. monocytogenes ATCC 7644 | 5.0 | 5.0 | 4.5 | 6.0 |
| B. subtillis ATCC 238557 | 8.5 | 7.0 | 6.0 | 10.0 |
| E. faecalis ATTC 29212 | 10.5 | 9.0 | 2.0 | 4.5 |
| S. aureus ATCC 25923 | 4.0 | 3.0 | 3.5 | 4.5 |
| S. pyrogenes ATCC 19615 | 5.0 | 2.5 | 5.0 | 8.5 |
| E. coli ATCC 25922 | 3.0 | 2.0 | 3.0 | 1.0 |
| K. pneumoniae ATCC 31488 | 2.5 | 2.0 | 2.5 | 2.0 |
| P. mirabilis ATCC 12453 | 3.0 | 1.0 | 3.0 | 2.0 |
| S. typhimurium ATCC 14028 | 5.5 | 1.5 | 3.5 | 2.0 |
| P. aereuginosa ATCC 27853 | 2.5 | 1.5 | 2.0 | 3.0 |
| E. aerogenes ATCC 13048 | 2.5 | 1.0 | 1.0 | 1.0 |
| C. krusei ATCC 14243 | 2.0 | 2.5 | 2.5 | 2.5 |
| C. albicans ATTC 10231 | 4.5 | 2.5 | 2.5 | 3.0 |