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Less B-cell linear epitopes on Receptor-binding domain (RBD) of Spike protein (S). (a) Amino acid sequence of RBD. Black bars indicate the corresponding peptides. The ACE-2 interacting interface was in red. (b) Reaction of COVID-19 convalescent sera with the peptides in RBD. The peptides with signal to noise above 2 were counted as positive (black bar). (c) Representative peptide (in black) in the structure of RBD (PBD, 6vyb).
