Scheme 1.
Reagents and conditions: (A) EtOH, reflux, 16 h; (B) 4-iodo-2-(methylthio)pyrimidine, Pd(OAc)2, Cs2CO3, PPh3, DMF, 80 °C, 12 h; (C) oxone, MeOH, H2O, rt, 16 h.
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