Scheme 3.
Reagents and conditions: (A) 12a-c, DIPEA, DMSO, 80 °C, 8 h; (B) 14a-f, DIPEA, DMSO, 80 °C, 8 h; (C) BBr3, CH2Cl2, –78 °C, 30 min then rt, 1 h.
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