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Antiproliferative activity (IC50 value, µM) of compound 1zb and sorafenib against melanoma cell lines and normal skin cells.a
| Cell line | 1zb | Sorafenib | |
|---|---|---|---|
| Melanoma cell lines | A375 | 0.46 ± 0.03 | 5.45 ± 0.53 |
| MDA-MB-435 | 0.59 ± 0.06 | 3.16 ± 0.20 | |
| SK-MEL-28 | 0.38 ± 0.05 | 2. 67 ± 0.15 | |
| UACC-62 | 0.18 ± 0.02 | 1.95 ± 0.08 | |
| Normal skin epithelial cell line | CCD1106K | 9.26 ± 0.38 | 11.57 ± 0.46 |
aThe results are expressed as means of triplicate assays ± SEM
