MyD88 signaling protects neonatal mice from RV disease. (A) Six-d-old mice were inoculated with 1 DD50 murine RV and observed daily for diarrhea symptoms, including the presence of yellow, runny and profuse feces with application of light pressure to the abdomen. Total RV diarrhea incidence amongst MyD88 KO and control mice were calculated. (B) The daily diarrhea rate, or the percentage of mice per d that displayed symptoms of diarrhea, was calculated. (C) The number of days each neonate experienced symptoms of diarrhea was averaged for MyD88 KO and control groups. Results in (A–C) represent the combination of two independent experiments where n = 9–15. In (C), bars denote the mean and error bars represent SEM. *P < 0.05; +P < 0.05.