Figure 4.

MyD88 signaling in adult mice enhances anti-RV Ab generation and proper Ab subtype switch. (A) Adult MyD88 KO and control mice were inoculated with RV and bled until 9 wk PI. Serum anti-RV IgG production, as represented by the OD value at a specified serum dilution, was analyzed by ELISA. The same serum was also probed for RV-specific (B) IgA, (C) IgG2c and (D) IgG1 in the same manner. Results are from an individual experiment (n = 5) and representative of three separate experiments that gave a similar pattern of results. Bars denotes the mean; error bars represent SEM; n = 5. *P < 0.05.