Figure 7.

MyD88 in radio-sensitive/bone marrow-derived cells but not radio-resistant cells assist in proper Ab sub-type switch. (A) WT mice reconstituted with MyD88 KO bone marrow were prepared as described in the Materials and methods, and serum was probed for RV-specific IgG2c and (B) IgG1 production. (C) MyD88 KO mice reconstituted with WT bone marrow were also made as described, and serum was probed for RV-specific IgG2c and (D) IgG1. (A) and (B) are representative of one independent experiment while (C) and (D) are representative of another independent experiment. Results are from an individual experiment (n = 4–5) with bars or horizontal lines representing the mean and error bars denoting the SEM. *P < 0.05.