Figure 8.

Anti-RV IgG and IgA is independent of bone marrow-derived IL-1 and IL-18; however, proper Ab subtype switch is dependent on both IL-1 and IL-18. (A) Bone marrow chimeric mice were made where WT mice were reconstituted with IL-1 and IL-18 DKO bone marrow. Mice were treated as described and serum RV-specific IgG and (B) IgA production was probed by ELISA. The same serum was also probed for the production of anti-RV (C) IgG2c and (D) IgG1. Results are from an individual experiment (n = 4–5) with bars or horizontal lines representing the mean and error bars denoting the SEM. *P < 0.05.