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. 2020 Oct 1;40(6):1574–1599. doi: 10.1148/rg.2020200149

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2020 by the Radiological Society of North America, Inc.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Schematic illustration of the effects of SARS-CoV-2 virus and virus-activated cytokine storm and their role in the development of ARDS and multiorgan failure (MOF). Note that a similar mechanism can be applied to any solid or hollow organ in the body that expresses ACE2 receptors on its surface. IFN-γ = interferon γ, IL-1 = interleukin-1, IL- 6 = interleukin-6, IL-8 = interleukin-8, TNF-α = tumor necrosis factor-α. — Schematic illustration of the effects of SARS-CoV-2 virus and virus-activated cytokine storm and their role in the development of ARDS and multiorgan failure (MOF). Note that a similar mechanism can be applied to any solid or hollow organ in the body that expresses ACE2 receptors on its surface. IFN-γ = interferon γ, IL-1 = interleukin-1, IL- 6 = interleukin-6, IL-8 = interleukin-8, TNF-α = tumor necrosis factor-α.