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. Author manuscript; available in PMC: 2020 Oct 5.
Published in final edited form as: Mech Dev. 2020 May 27;163:103617. doi: 10.1016/j.mod.2020.103617

Figure 1: Anterior-posterior axis patterning positions the primitive streak prior to gastrulation.

Figure 1:

After implantation, the embryo transitions from using the proximal-distal axis to the embryonic anterior-posterior (AP) axis. The establishment of this axis depends on a sequence of events including specification of the DVE at E5.5 and formation and migration (dashed black arrow) of the AVE at E5.75. The primitive streak is restricted to the posterior pole by E6.5 and elongates distally and anteriorly (white dashed arrow) until E7.5. Solid arrows indicate activation, bar-headed lines indicate inhibition. Adapted from (Rivera-Pérez and Hadjantonakis, 2015).