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. 2020 Jun 30;128(6):067015. doi: 10.1289/EHP6263

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Figure 1 is a Manhattan plot, plotting negative log of 10 (p-value), ranging from 1 to 10 in unit increments (y-axis) across chromosome, ranging from 1 to 22 in unit increments (x-axis). Approximately, Bonferroni approximately 7.2 and the FDR threshold should be approximately 5.9. — Manhattan plot for the epigenome-wide association of log(total urinary arsenic levels) and DNA methylation levels. limma models adjusted for age, sex, BMI, self-reported smoking status, education ( $< high school$ , high school graduate or GED, $> high school$ ), study center (Arizona, Oklahoma, North and South Dakota), estimated glomerular filtration rate, and cell-type proportion estimates. The solid line represents the Bonferroni threshold, and the dashed line represents the FDR threshold for significance. Note: BMI, body mass index; FDR, false discovery rate; GED, General Education Diploma.