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. 2020 Jun 30;128(6):067015. doi: 10.1289/EHP6263

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figure 2 is a volcano plot, plotting negative log to the base 10 of (p-value), ranging from 0.0 to 10.0 in increments of 2.5 (y-axis) across effect estimate (M value scale), ranging from negative 0.3 to 0.2 in unit increments (x-axis). Approximately, Bonferroni threshold to 7.2, and FDR threshold is marked at 5.9. — Volcano plot for the epigenome-wide association of log(total urinary arsenic levels) and DNA methylation levels. Limma models adjusted for age, sex, BMI, self-reported smoking status, education ( $< high school$ , high school graduate or GED, $> high school$ ), study center (Arizona, Oklahoma, North and South Dakota), estimated glomerular filtration rate, and cell-type proportion estimates. The solid line represents the Bonferroni threshold and the dashed line represents the FDR threshold for significance. Note: BMI, body mass index; FDR, false discovery rate; GED, General Education Diploma.