. 2020 Jun 30;128(6):067015. doi: 10.1289/EHP6263

Table 3.

CpGs Located in the differentially methylated region chr11:2,322,050-2,323,247.

CpG	Position^a	Gene	Feature category	$p$ -Value	Median % methylation^b	Mean difference in % methylation (95% CI)^c
cg25961099	2322050	C11orf21; TSPAN32	Body; TSS1500	0.019	9.02	0.08 ( $- 0.11$ , 0.26)
cg01211906	2322286	C11orf21; TSPAN32	Body; TSS1500	0.002	2.91	0.10 (0.02, 0.18)
cg09114153	2322329	C11orf21; TSPAN32	Body; TSS1500	0.009	9.09	0.40 (0.15, 0.64)
cg01612681	2322386	C11orf21; TSPAN32	Body; TSS1500	$1.46 \times 10^{- 4}$	1.12	0.17 (0.06, 0.29)
cg13592872	2322500	C11orf21; TSPAN32	Body; TSS1500	0.502	4.20	0.28 (0.12, 0.45)
cg21027517	2322507	C11orf21; TSPAN32	Body; TSS1500	0.150	3.80	0.27 (0.08, 0.46)
cg05509777	2322517	C11orf21; TSPAN32	Body; TSS1500	0.096	3.75	0.37 (0.14, 0.60)
cg10782575	2322543	C11orf21; TSPAN32	Body; TSS1500	0.001	10.77	0.49 (0.18, 0.81)
cg00502099	2322618	C11orf21; TSPAN32	Body; TSS1500	0.092	1.18	0.09 ( $- 0.02$ , 0.20)
cg03494648	2322642	C11orf21; TSPAN32	Body; TSS1500	$4.05 \times 10^{- 4}$	1.06	0.02 ( $- 0.02$ , 0.05)
cg15924868	2322674	C11orf21; TSPAN32	Body; TSS1500	0.024	0.57	0.03 (0.00, 0.05)
cg02537342	2322729	C11orf21; TSPAN32	Body; TSS1500	0.001	6.96	0.04 ( $- 0.15$ , 0.22)
cg00041575	2322741	C11orf21; TSPAN32	Body; TSS1500	$2.12 \times 10^{- 4}$	1.61	0.06 ( $- 0.02$ , 0.15)
cg05403469	2322781	C11orf21; TSPAN32	Body; TSS1500	0.048	1.34	$- 0.01$ ( $- 0.13$ , 0.12)
cg19766471	2322802	C11orf21; TSPAN32	Body; TSS1500	0.005	11.75	0.72 (0.29, 1.16)
cg22210337	2322808	C11orf21; TSPAN32	Body; TSS1500	0.002	11.46	1.05 (0.40, 1.70)
cg21201830	2323056	C11orf21; TSPAN32	Body, 1stExon; TSS200	0.003	1.80	0.13 (0.01, 0.25)
cg15579389	2323059	C11orf21; TSPAN32	Body, 1stExon; TSS200	0.003	0.89	0.04 ( $- 0.01$ , 0.09)
cg09358071	2323083	C11orf21; TSPAN32	Body, 1stExon; TSS200	$9.33 \times 10^{- 4}$	0.92	0.04 (0.01, 0.07)
cg05572370	2323247	C11orf21; TSPAN32	TSS200, 1stExon; 5′UTR	0.337	2.22	0.08 ( $- 0.02$ , 0.17)

Note: BMI, body mass index; CI, confidence interval; GED, General Education Diploma: .

^{^a}

GRCh37/hg19 assembly.

^{^b}

Percent methylation calculated $Beta-value \times 100$ .

^{^c}

Effect size estimate from limma models of Beta-values [i.e., mean difference in percent methylation for each unit change in ln(total urinary arsenic levels)] adjusted for age, sex, BMI, self-reported smoking status, education ( $< high school$ , high school graduate or GED, $> high school$ ), study center (Arizona, Oklahoma, North and South Dakota), estimated glomerular filtration rate, and cell type proportion estimates.