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Low-Energy Binding Conformations of Imatinib to Furin Generated by Molecular Docking
(A) Imatinib was fitted well in the active pocket of human furin, and furin was shown as electrostatic surface model. Imatinib (yellow) was overlapped with substrate analog inhibitor MI-52 (purple).
(B) Detailed view of Imatinib binding in the active pocket of furin.
