Table 1.
Furin Cleavage Probability of Spike Sequence Homology
| Description | Accession No. | CS1 Sequence | Furin Scorea | Identityb |
|---|---|---|---|---|
| SARS-CoV-2 | QHR63250.1 | NSPRRAR/SV | 0.620 | 100% |
| Bat-CoV-RaTG13 | QHR63300.1 | QTQTNSR/SV | 0.151 | 97.4% |
| Bat-SL-CoV | AVP78042.1 | HTASILR/ST | 0.170 | 80.3% |
| SARS-CoV | ABF68955.1 | QLTPAWR/IY | 0.117 | 76.0% |
| Bat-CoV HKU5 | AGP04941.1 | PSARLAR/SD | 0.697 | 37.1% |
| MERS-CoV | QBM11737.1 | LTPRSVR/SV | 0.563 | 35.0% |
| Rat-CoV | AFG25760.1 | TAHRARR/SV | 0.879 | 36.3% |
| MHV | ABS87264.1 | TSHRARR/SI | 0.861 | 36.9% |
| HCoV-HKU1 | AGT17758.1 | SSRRKRR/GI | 0.744 | 36.8% |
| Rodent-CoV | ATP66727.1 | TARRKRR/AL | 0.795 | 37.3% |
| β-CoV sp | AYR18670.1 | ATRRAKR/DL | 0.753 | 35.9% |
| Equine-CoV | BAS18866.1 | TARRQRR/SP | 0.815 | 37.1% |
| Porcine-CoV | ARC95227.1 | TSLRSRR/SL | 0.758 | 36.1% |
| Bovine-CoV | QGW57589.1 | TKRRSRR/AI | 0.780 | 37.5% |
| Canine-CoV | ABG78748.1 | TQRRSRR/SI | 0.832 | 37.1% |
| Camel-CoV HKU23 | ALA50080.1 | IDRRARR/FT | 0.718 | 36.5% |
| Rabbit-CoV HKU14 | AFE48805.1 | TLQPSRR/AI | 0.629 | 37.7% |
| Human-CoV OC43 | AMK59677.1 | KTRRSRR/AI | 0.720 | 36.8% |
a
Scores are predicted by ProP 1.0 Server. Scores above 0.5 mean furin cleavable.
b
Identities compared with SARS-CoV-2 Spike protein.